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(CHEM 201) Synthesis of 1-bromobutane

Sandra Watson
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Synthesis of 1-bromobutane- Grade: 95

  • UniversityTarleton State University
  • CourseOrganic Chemistry I (CHEM 201)

SN2 reactions are nucleophilic substitution reactions whose rates are dependent on the
nucleophile and the substrate. The mechanism in an SN2 is concerted, meaning that it occurs in
one single step instead of a series of steps. Unlike SN1 reactions, SN2 reaction mechanisms have
a transition state. The techniques used in the experiment included refluxing and distillation. In
this experiment, we conducted the synthesis of 1-bromobutane by SN2 reaction of protonated
alcohol with a bromide ion.


 In a 25 mL round bottom flask, add 2.4 mL of 1-butanol plus 4.0 mL of HBr
(hydrobromic acid).
 To the mixture of 1-butanol and HBr add the magnetic stir bar and slowly add 2.0 mL of
concentrated sulfuric acid.
 Set up the reflux apparatus as shown by the diagram in the lab manual and reflux the
reaction mixture using a heating mantle for 1 hour.
 After 1 hour has passed, remove the flask from the heating source and wait until it is cool
enough to touch.



(CHEM 201) Synthesis of 1-bromobutane

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