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Genetics (NUR 4160) Cardiovascular Disorders CH13

John Marsh
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Nova Southeastern University

Genetics For Nursing Practice (NUR 4160)

Cardiovascular Disorders – Practice Questions – CH13

Chapter 13: Cardiovascular Disorders
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Which condition or factor for coronary artery disease (CAD) suggests a greater genetic contribution
than environmental contribution to its development?
A. When a person develops CAD 5 years after quitting smoking
B. When CAD occurs in a person who has normal blood pressure
C. When CAD is diagnosed in a person who is younger than 50 years
D. When low-density lipoprotein levels can be reduced by dietary changes alone
____ 2. The process in which gene variants interact with other gene variants to cause disease can be
described by what word/phrase?
A. Phenotype variation
B. Reduced penetrance
C. Epistasis
D. Variable expressivity
____ 3. What is the most accurate classification of the common forms of coronary artery disease and
A. Secondary disorders caused by lifestyle choices
B. Sequential genetic disorders related to age, ethnicity, and gender
C. Complex disorders resulting from gene–environment interactions
D. Primary disorders with an autosomal-dominant pattern of inheritance
____ 4. What is the genetic contribution to the development of the most common forms of atherosclerosis?
A. Variation in a variety of genes, with each exerting a small effect
B. Disordered mitochondrial function reducing energy production
C. Genetic predisposition expressed after exposure to a viral trigger
D. Single-gene mutation following autosomal-dominant inheritance
____ 5. Your 40-year-old patient is hospitalized for a myocardial infarction, but her lipid levels are normal.
She says that she would like to have a genetic test to see why she was affected at such a young age.
What do you say?
A. “Heart attacks seem to be caused by a combination of many affected genes
working together as well as environmental factors. There is no single gene test that
will be able to identify why this happened to you.”
B. “Let’s talk with your nurse practitioner about scheduling a test for familial
C. “You really shouldn’t be concerned about your genetic risk. Because you are
female, it is very low.”
D. “It was just bad luck combined with the fact that you were once a smoker.”
____ 6. Which variable in a person with coronary artery disease (CAD) increases the likelihood of a strong
genetic influence in its expression?
A. The disorder is not present in the person’s dizygotic twin.
B. The disorder is present in a woman whose father had CAD.
C. The affected person has eaten a vegetarian diet for the past 5 years.
D. The disorder is present in about 5% of the person’s maternal family members.
____ 7. Which total plasma cholesterol levels are most likely to be present in people who are homozygous
for an allele that causes familial hypercholesterolemia?
A. 100 mg/dL to 200 mg/dL
B. 200 mg/dL to 300 mg/dL
C. 400 mg/dL to 500 mg/dL
D. 600 mg/dL to 1,200 mg/dL
____ 8. Which problem associated with Tangier disease increases the risk for coronary artery disease?
A. Low levels of triglycerides
B. High levels of triglycerides
C. Low levels of high-density lipoproteins (HDLs)
D. High levels of low-density lipoproteins (LDLs)
____ 9. Which physical finding in a 30-year-old man suggests the possibility of familial
A. Lipomas
B. Xanthomas
C. Osteoarthritis
D. Hemangiomas
____ 10. For patients who have familial hypercholesterolemia, what should be the focus of teaching for blood
cholesterol reduction?
A. Eliminating animal fats from the diet
B. Increasing the amount of fruit in the diet
C. Exercising at least 4 to 5 hours every week
D. Taking the lipid-lowering drug as prescribed



Genetics (NUR 4160) Cardiovascular Disorders CH13

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