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NUR 4160 Assessing Genomic Variation In Drug Response - CH17

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Assessing Genomic Variation in Drug Response – CH17-which processes of drug response are most subject to genetic variation?

  • Nova Southeastern University
  • Genetics For Nursing Practice (NUR 4160)

Chapter 17: Assessing Genomic Variation in Drug Response
Multiple Choice
Identify the choice that best completes the statement or answers the question.
__D.__ 1. Which of the following is a goal of pharmacogenetics?
A. Producing “blockbuster drugs” that will work equally well for everyone
B. Bringing down the cost of pharmaceutical manufacturing
C. Developing drugs that will treat very rare diseases
D. Reducing adverse reactions
__C.__ 2. Which processes of drug response are most subject to genetic variation?
A. Drug dissolution in body fluids and drug binding to plasma proteins
B. Rates of drug movement into and through the gastrointestinal tract
C. Drug activation or deactivation and duration of drug actions
D. Drug binding with receptors and drug blocking of receptors
__A.__ 3. Which statement about agonist and antagonist drugs is true?
A. Both drugs types must interact with receptors to produce their intended responses.
B. The primary target tissues for these types of drugs are invading bacteria and
viruses.
C. Antagonists drugs produce only intended responses, and agonist drugs produce
both intended responses and side effects.
D. These types of drugs are less likely to cause allergic responses than drugs that are
neither agonists nor antagonists.
__B.__ 4. What is the expected heart-rate response when a patient is taking a drug that is an adrenaline
antagonist?
A. Heart rate is unchanged.
B. Heart rate decreases.
C. Heart rate increases.
D. Heart rate is irregular.
__A.__ 5. How do genetic/genomic issues influence individual variation in the response to a specific drug?
A. Polymorphisms of genes encoding metabolizing enzymes
B. Age-related loss of alleles within the cells lining the intestinal tract
C. Single-gene disorders that reduce the function of the kidneys or the liver
D. Genetic-based behavior problems that promote poor adherence to prescribed drug
regimens

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NUR 4160 Assessing Genomic Variation In Drug Response - CH17

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