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(NURS 120 ) Mosby’s Pharmacology Memory Notecards

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John Marsh
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Mosby’s Pharmacology Memory Notecards Visual, Mnemonic, and Memory Aids

  • UniversityBellevue College
  • CourseNursing Fundamentals (NURS 120 )

Second-Generation NSAIDs (COX-2 Inhibitor, Coxib:
Celebrex)
Classification
Analgesic, antiinflammatory; nonsteroidal antiinflammatory drug (NSAID)
Action
Inhibits prostaglandin synthesis by selectively inhibiting cyclooxygenase 2 (COX-2), an enzyme
needed for biosynthesis, which suppresses pain and inflammation while posing a lower risk of
gastric ulceration
Uses
• Relieves low-to-moderate pain
• Decreases inflammation in systemic lupus erythematosus, rheumatoid arthritis,
osteoarthritis
Contraindications and Precautions
• May increase the risk of myocardial infarction (MI) and stroke and other serious
cardiovascular events.
• Do not use during pregnancy, especially the third trimester.
• Can impair renal function.
• Can precipitate an allergic reaction in patients allergic to sulfonamides.
• Do not use in patients with a history of hypertension, edema, heart failure, or kidney
disease.
Side Effects
• Dyspepsia, abdominal pain, fatigue, nervousness, paresthesia
• Does not decrease platelet aggregation; hence, does not promote bleeding
Nursing Implications
1. Give with milk or full glass of water to enhance absorption.
2. Do not break, crush, chew, or dissolve caps. Caps can be opened into applesauce or soft
food, but must be ingested immediately with water.
3. Teach patient to avoid concurrent use of alcohol to decrease gastrointestinal (GI) irritation.
4. Monitor for GI irritation, bleeding episodes, or renal impairment.
5. Evaluate patient to determine purpose of medication—reduction in pain and inflammation.
6. Teach patient to avoid use of NSAIDs to prevent vaccination-associated fever and pain, as
they may blunt the immune response to the vaccine.

Acetaminophen (Tylenol)
Classification
Analgesic, antipyretic
Action
Decreases prostaglandin synthesis in the CNS and has antipyretic and analgesic action. Does not
possess antiinflammatory properties, does not cause gastric ulceration, does not suppress platelet
aggregation or impair renal blood flow or function.
Uses
• Relieves low-to-moderate pain, fever
• Arthralgia, dental pain, dysmenorrhea, headache
• Preferred drug for children having chickenpox or influenza (not associated with Reye
syndrome)
Contraindications and Precautions
• Hypersensitivity
• Precaution during pregnancy and breast-feeding
• Excessive alcohol ingestion
Side Effects
• Adverse effects rare at therapeutic doses
• Overdose or toxicity leads to liver damage
Nursing Implications
1. Give with milk or full glass of water to decrease gastric irritation.
2. Teach parents that drug may blunt the immune response to childhood vaccines and should
not be given to treat pain or fever associated with the vaccination.
3. Teach patient to avoid concurrent use of alcohol to prevent liver damage.
4. Evaluate patient to determine purpose of medication—pain or fever.
5. Antidote for overdose is acetylcysteine (Mucomyst).
6. If patient is taking warfarin (Coumadin), concurrent use of acetaminophen has ability to
increase risk of bleeding.
7. Monitor medications that may contain acetaminophen, so as not to exceed maximum

 

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(NURS 120 ) Mosby’s Pharmacology Memory Notecards

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