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Pharmacological Basis For Nursing Interventions I (NUR 3191) Nova Southeastern University

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John Marsh
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Pharmacological Basis For Nursing Interventions I (NUR 3191) Nova Southeastern University

Exam 1 Notes – Summary Pharmacological Basis For Nursing Interventions I
PHARMACOLOGY AND THE NURSING PROCESS BY LILLEY RAINFORTH COLLINS SNYDER

Ch 2 DRUGS AFFECTING THE CNS
Pharmaceutics – Study of how dosage influences drug metabolism
Pharmacokinetics
-Study of what body does to drug molecules
-Involves processes of absorption, distribution, metabolism & excretion
-Time to onset, time to peak effect, and duration of action
-Absorption – movement of drug into bloodstream
-Bioavailability – extent of drug absorption
oIV drugs 100% bioavailable
-First-pass effect – reduces bioavailability of a drug (chemically processed into inactive
metabolites)
oHepatic arterial
oOral
oPortal venous
oRectal
Routes of Administration
-Enteral
oAbsorbed into systemic circulation through mucosa of stomach and/or intestines.
oNormally goes from intestines into blood to liver then metabolized, then remaining
active ingredients are passed into general circulation
oPresence of food in stomach may enhance absorption of some fat-soluble drugs
-Sublingual – absorbed rapidly (bypasses liver)
-Parenteral
oFastest route of absorption
oRoute other than GI tract
oBypass first-pass effect of liver
-Topical
oMore uniform amount of drug over longer period
oSlower onset
oAvoids first-pass effect of liver
oIncludes inhaled drugs
Distribution
-Rapid – heart, liver, kidneys, brain
-Slower – muscle, skin, fat

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Pharmacological Basis For Nursing Interventions I (NUR 3191) Nova Southeastern University

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