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Pharmacological Basis (NUR 3192) Pharm W7C7E2 Antilipemic Drugs

John Marsh
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Nova Southeastern University

Pharmacological Basis For Nursing Interventions II (NUR 3192)

Pharm II W7C7E2 Antilipemic Drugs

Chapter 27: Antilipemic Drugs
Primary Forms of Lipids
 Triglycerides and cholesterol are the two primary forms of lipids in the blood
o Triglycerides function as an energy source and are stored in adipose tissue
o Cholesterol is primarily used to make steroid hormones, call membranes, and
bile acids
 Both are water-insoluble fats that must be bound to specialized lipid-carrying proteins
called apolipoproteins
o The combination of triglycerides and cholesterol with apolipoprotein is referred
to as a lipoprotein
 Lipoproteins transport lipids via the blood
Cholesterol Homeostasis
 Fats are taken into the body through the diet and are broken down in the small intestine
to form triglycerides. Triglycerides are then incorporated into chylomicrons in the cells
of the intestinal walls and are absorbed into the lymphatic system.
o The primary purpose of chylomicrons is to transport lipids obtained from dietary
sources (exogenous lipids) from the intestines to the liver to be used to take
steroid hormones, lipids structural components for peripheral body cells, and
bile acids
 The liver is the major organ where lipid metabolism occurs
o The liver produces very-low density lipoprotein (VLDL) from both endogenous
and exogenous sources
 VLDL – transport of endogenous lipids to peripheral cells
o HDL is produced in the liver and intestines and is also formed when chylomicrons
are broken down



Pharmacological Basis (NUR 3192) Pharm W7C7E2 Antilipemic Drugs

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