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The Dynamic Cell 2 (BILG08009) F1-F0 ATP Synthase - Paul Mclaughin's Lecture Notes

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The University of Edinburgh

The Dynamic Cell 2 (BILG08009)

F1Fo- ATP synthase
Introduction
Lecture presentation on the web
Links to the presentation given in the lecture are on the course web site. These do not contain any notes or
comments made in the lecture. This is a deliberate policy so that attending the lecture is not redundant.
Movies and animations used are available there so that you can work through them in your own time, if you
wish. These notes will be available at one page per A4 size as a pdf file on the web-site.
Contacting Lecturer
E-mail is probably the quickest and most reliable way
E-mail: [email protected]
Telephone: 6507060
Location: Room 3.26, Michael Swann Building
References
 Alberts, BM, et al. Molecular Biology of the Cell. 5th edition. Garland Science,New York, Chapter 14
 Berg, JM, Tymoczko JL & Stryer L, Biochemistry W.H.Freeman and Company, New York, 5th
edition, Chapter 18.
Aims
You should be able:
 sketch a working model of FoF1 ATP synthase to illustrate how proton translocation through the
complex promotes ATP synthesis; appreciate how the complex can be forced to work in reverse.
ATP synthase – a proton pump coupled to ATP synthesis
 Oxidative Phosphorylation establishes a proton
gradient across inner mitochondrial membrane
 Since asymmetric distribution of ions, energy
needed to produce this (i.e. oxidation): it is also
an energy source – used by cell to make ATP.
 How is this coupled?

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The Dynamic Cell 2 (BILG08009) F1-F0 ATP Synthase - Paul Mclaughin's Lecture Notes

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